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A PHP Error was encountered
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Message: Creation of dynamic property Produk::$config is deprecated
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A PHP Error was encountered
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Message: Creation of dynamic property Produk::$utf8 is deprecated
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A PHP Error was encountered
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Message: Creation of dynamic property Produk::$uri is deprecated
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Message: Creation of dynamic property Produk::$exceptions is deprecated
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Message: Creation of dynamic property Produk::$router is deprecated
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Message: Creation of dynamic property Produk::$output is deprecated
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Message: Creation of dynamic property Produk::$security is deprecated
Filename: core/Controller.php
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Message: Creation of dynamic property Produk::$input is deprecated
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Message: Creation of dynamic property Produk::$lang is deprecated
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Message: Creation of dynamic property Produk::$load is deprecated
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Message: Creation of dynamic property Produk::$db is deprecated
Filename: core/Loader.php
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A PHP Error was encountered
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Message: Creation of dynamic property Produk::$session is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property Produk::$form_validation is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property Produk::$simple_login is deprecated
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Message: Creation of dynamic property Produk::$user_model is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property Produk::$konfigurasi_model is deprecated
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Message: Creation of dynamic property Produk::$site_model is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property Produk::$produk_model is deprecated
Filename: core/Loader.php
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A PHP Error was encountered
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Message: Creation of dynamic property Produk::$kategori_produk_model is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property CI_Loader::$benchmark is deprecated
Filename: core/Loader.php
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File: /home/u1602957/public_html/didikkurnia/application/controllers/Produk.php
File: /home/u1602957/public_html/didikkurnia/index.php
A PHP Error was encountered
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Message: Creation of dynamic property CI_Loader::$hooks is deprecated
Filename: core/Loader.php
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File: /home/u1602957/public_html/didikkurnia/application/controllers/Produk.php
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A PHP Error was encountered
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Message: Creation of dynamic property CI_Loader::$config is deprecated
Filename: core/Loader.php
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A PHP Error was encountered
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Message: Creation of dynamic property CI_Loader::$log is deprecated
Filename: core/Loader.php
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Filename: core/Loader.php
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Message: Creation of dynamic property CI_Loader::$uri is deprecated
Filename: core/Loader.php
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File: /home/u1602957/public_html/didikkurnia/application/controllers/Produk.php
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Message: Creation of dynamic property CI_Loader::$exceptions is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property CI_Loader::$router is deprecated
Filename: core/Loader.php
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File: /home/u1602957/public_html/didikkurnia/index.php
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Message: Creation of dynamic property CI_Loader::$output is deprecated
Filename: core/Loader.php
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File: /home/u1602957/public_html/didikkurnia/index.php
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Message: Creation of dynamic property CI_Loader::$security is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property CI_Loader::$input is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property CI_Loader::$lang is deprecated
Filename: core/Loader.php
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Message: Creation of dynamic property CI_Loader::$load is deprecated
Filename: core/Loader.php
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File: /home/u1602957/public_html/didikkurnia/index.php
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SIFAT SITOTOKSIK DARI EKSTRAK KULIT BATANG CHISOCHETON PENTANDRUS (MELIACEAE) TERHADAP SEL KANKER PAYUDARA MCF-7
SIFAT SITOTOKSIK DARI EKSTRAK KULIT BATANG CHISOCHETON PENTANDRUS (MELIACEAE) TERHADAP SEL KANKER PAYUDARA MCF-7
SIFAT SITOTOKSIK DARI EKSTRAK KULIT BATANG CHISOCHETON PENTANDRUS (MELIACEAE) TERHADAP SEL KANKER PAYUDARA MCF-7
Description
Chisocheton (Meliaceae) merupakan salah satu tumbuhan Indonesia yang secara emiris digunakan untuk mengobati penyakit kanker. Pada penelitian ini dilakukan uji sitotoksik dari ekstrak kulit batang tumbuhan C. pentandrus terhadap sel kanker payudara MCF-7. Ekstraksi dilakukan dengan menggunakan metode maserasi. Fraksinasi dilakukan dengan metode fraksinasi cair-cair. Uji sifat sitotoksik dilakukan dengan metode uji MTT assay. Hasil penelitian menunjukkan nilai IC50 dari ekstrak MeOH, EtOAc, dan CHCl3 berturut-turut sebesar 480,28, 434,15, dan 151,39 µg/mL. Ekstrak kloroform menunjukkan sifat sitotoksik cukup aktif.
Kata kunci: Chisocheton pentandrus, kulit batang, sitotoksik, sel kanker MCF-7.
Chisocheton (Meliaceae) is one of the Indonesian plants which empirically used to treat cancer. In this study, we reprted a cytotoxic properties of C. pentandrus stem bark extract on MCF-7 breast cancer cells. Extraction was carried out using the maceration method. Fractionation is carried out by the liquid-liquid fractionation method. Cytotoxic properties were tested using the MTT assay test method. The results showed the IC50 values of MeOH, EtOAc, and CHCl3 extracts were 480.28, 434.15, and 151.39 µg/mL, respectively. Chloroform extract shows moderate cytotoxicity on MCF7 breast cancer cells line.
Key words: Chisocheton pentandrus, stem bark, cytotoxic, MCF-7 cancer cells line.
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